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Effect of nitric oxide on the attenuation of acquisition of morphine-induced conditioned place preference by the essential oil from Cuminum cyminum L. fruit in mice

Author(s): Pegah Azizi | Mojtaba Kermani | Abbas Haghparast

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 15;
Issue: 3;
Start page: 435;
Date: 2011;
Original page

Keywords: Cuminum cyminum | Nitric oxide | Morphine | L-Arginine | Conditioned place preference | Acquisition | Mice

Introduction: Nitric oxide (NO) is a neuronal messenger molecule in the central nervous system, which is generated from L-arginine by nitric oxide synthase (NOS) and involves in many important opioid-induced effects. Our previous studies revealed that Cuminum cyminum interestingly reduces morphine sensitization, tolerance and dependency in male mice. Therefore, in the present study, the effect of intraperitoneal (ip) administration of different doses of cumin fruit essential oil (FEO) on the acquisition of morphine-induced conditioned place preference (CPP) in L-arginine treated mice was investigated. Methods: In this study, the CPP paradigm was done on 231 adult male albino Wistar mice and conditioning scores and locomotor activity were recorded by the Ethovision software. Results: The results showed that solely administration of different doses of cumin FEO (0.01, 0.1, 0.5, 1 and 2%; ip) or L-arginine (50, 100 and 200 mg/kg; ip) during CPP protocol could not induce CPP. Nonetheless, morphineinduced CPP was significantly decreased by two higher doses of cumin FEO (1% and 2%; P
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