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The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats

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Author(s): Mohsen Khalili

Journal: Basic and Clinical Neuroscience
ISSN 2008-126X

Volume: 1;
Issue: 1;
Start page: 29;
Date: 2009;
Original page

Keywords: Withania somnifera | Analgesia | Diabetes mellitus | Streptozotocin | Rat

ABSTRACT
  Abstract  Introduction: Hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. With c onsidering the potential anti-diabetic effect of the medicinal plant Withania somnifera (WS)( ashwagandha), this study was designed to investigate the analgesic effect of WS on formalin-induced nociceptive responses (standard formalin test) in diabetic rats. Methods: Rats were divided into control, WS-treated control, diabetic, sodium salicylate (SS)-treated control and diabetic and WS-treated diabetic groups. For induction of diabetes, streptozotocin (STZ) was used at a single dose. The treatment groups received oral administration of ashwagandha -mixed rat pellet (6.25%) for two months.  Results: The results showed that diabetic rats exhibited a higher score of pain at both phases of the formalin test and WS-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (p

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