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The Effect of Organophosphate Pesticides on the Blood Glucose Levels in the Mouse

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Author(s): Goudarz Sadeghi-Hashjin | Mahdieh Moslemi | Shahram Javadi

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 11;
Issue: 9;
Start page: 1290;
Date: 2008;
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Keywords: Organophosphates | malathion | azinphos methyl | mouse | blood glucose

ABSTRACT
The aim of the present study was to study the effect of two selected agents of this group on blood glucose levels in an animal model. Forty-two adult male mice were divided into 7 groups of 6 each. Animals were exposed by their entire tail for 10 sec once a day for 7 successive days to either 0, 0.1, 1, or 10% azynphos methyl (AZP) malathion (MLT). On days 1, 4 and 8, a small drop of blood was taken from tail of the animals that had been kept fasted overnight. Blood glucose levels were measure using a glucometer. The animals then were fed and after 1 h the blood glucose measurement was performed again. Results of this study indicated that the administration of organophosphate agents significantly prevented from the rise of blood glucose after feeding in comparison to the control animals. This reached the level of statistical significance on day 1 with MLT 1% (p
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