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EFFECT OF PENETRATION ENHANCER ON IN VITRO RELEASE OF DICLOFENAC SODIUM GEL FORMULATION

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Author(s): Hitesh Jain

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 11;
Start page: 3;
Date: 2011;
Original page

Keywords: Diclofenac sodium | Skin | Transdermal | Permeation enhancer

ABSTRACT
Transdermal drug therapy has been one of the major research fields in the area of drug therapy for last few decades. However inspite of its large therapeutic potential market success has been limited. It provides the several advantages over the oral drug delivery. The skin is very effective as a selective penetration barrier. Percutaneous absorption involves the passage of the drug molecule from the skin surface into the stratum corneum under the influence of a concentration gradient and its subsequent diffusion through the stratum corneum and underlying epidermis, through the dermis, and into the blood circulation. The skin behaves as a passive barrier to the penetrant molecule. The stratum corneum provides the greatest resistance to penetration, and it is the rate limiting step in percutaneous absorption studies have been carried out to find safe and suitable permeation enhancers to promote the percutaneous absorption of a number of drugs. Penetration enhancers represent a popular method of increasing drug flux through the skin for local or systemic activity. Here the influence of different concentrations of oleic acid (1% and 3%) in gel formulations on percutaneous penetration of diclofenac sodium was investigated using Franz-type diffusion cells and egg membrane. The results of permeation studies showed that oleic acid enhance the percutaneous penetration and 3 % oleic acid was found to be more effective as a penetration enhancer.
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