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Effect of Quercus infectoria and Rosa damascena on Lipid Profile and Atherosclerotic Plaque Formation in Rabbit Model of Hyperlipidemia

Author(s): A. Gholamhoseinian | B. Shahouzehi | S. Joukar | M. Iranpoor

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 15;
Issue: 1;
Start page: 27;
Date: 2012;
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Keywords: Quercus infectoria | HMG CoA reductase and pancreatic lipase | hyperlipidemic rabbit | Rosa damascena

Hyperlipidemia is the cause of many complications in the human societies. In this study, the effect of methanol extracts of Quercus infectoria (QI) galls and Rosa damascena (RD) Mill flower were studied on lipid profile and atherosclerotic plaques formation in hyperlipidemic rabbits. Thirty-six New Zeland white rabbits randomly divided into 6 groups as control (I), hyperlipidemic (II), hyperlipidemic+QI (III), hyperlipidemic+RD (IV), +Atorvastolin (V) and hyperlipidemic+Orlistat (VI) and were fed with high fat diet (0.5% cholesterol and 16% hydrogenated vegetable oil) for 45 days. At the end of the study period, lipid profile and plaque formation were assessed. Total Cholesterol (TC), Low Density Lipoprotein (LDL) and Triglyceride (TG) levels were significantly increased in hyperlipidemic group compared with control group (p

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