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Effect of serotonin depletion in the paraventricular nucleus of the hypothalamus on the behavioral responses in the rat

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Author(s): Lucian Hritcu | Alin Ciobica | Sorin Stratulat

Journal: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
ISSN 1582-3571

Volume: 9;
Issue: 4;
Date: 2008;
Original page

ABSTRACT
Male Wistar rats were subjected to right-unilateral 5,7-dihydroxytryptamine (5,7-DHT) lesion (8μg/3μl and 16μg/3μl) of the paraventricular nucleus of the hypothalamus (PVN) or were sham-operated, and their ability to acquire the operant task was studied by means of Y-maze and radial 8 arm-maze tasks. Serotonin depletion in the PVN non-significantly increased the spontaneous alternation percentage in Y-maze task. 5,7-DHT non-significantly increased the number of working memory errors and significantly increased the number of reference memory errors in radial 8 arm-maze task, suggesting effects on spatial memory formation, especially on long-term memory. In elevated plus maze measuring anxiety, 5,7-DHT significantly diminished anxiety state. In summary, we provided that the serotonin level in the PVN influences learning and memory processes.

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