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EFFECT OF SHORT TERM EXPOSURE OF BUTYLPARABEN ON UTERINE WEIGHT OF OVARIECTOMISED C3H ALBINO MICE

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Author(s): Pallabi Goswami | J.C Kalita

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 150;
Date: 2012;
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Keywords: Butylparaben | estrogen | uterotrophic assay | reproductive toxicity.

ABSTRACT
Butylparaben is a commonly used anti microbial preservative in cosmetics, pharmaceuticals and food. The high rate of human exposure of butylparaben has been of growing concern as it is found to mimic estrogen activity in in vitro and in vivo system. Studies showed that butylparaben exerts reproductive toxicity in experimental animals. Several studies report in vivo estrogenic effect in CD1 and CF1 mice and there are known strain differences in sensitivity to endocrine disruption. In this experiment sensitivity of butylparaben exposure on uterus of ovariectomised C3H albino mice was studied through uterotrophic assay considering 5 different doses of 10 mg/Kg body weight/day, 50 mg/Kg body weight/day, 100 mg/Kg body weight/day, 500 mg/Kg body weight/day, 1000 mg/Kg body weight/day for 7 consecutive days through subcutaneous route of administration. The ovariectomised C3H albino mice were grouped as vehicle control (olive oil), positive control (estradiol) and the above five different doses of Butylparaben. After the short term exposure of 7 days butylparaben is found to exert a dose dependent change in uterine weight of ovariectomised C3H albino mice.
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