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The Effect of Si-Doping on the Release of Antibiotic from Hydroxyapatite Coatings

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Author(s): Mirjam Lilja | Carl Lindahl | Wei Xia | Håkan Engqvist | Maria Strømme

Journal: Journal of Biomaterials and Nanobiotechnology
ISSN 2158-7027

Volume: 04;
Issue: 03;
Start page: 237;
Date: 2013;
Original page

Keywords: Titanium Dioxide | Hydroxyapatite | Cephalothin | Drug Release | Si-Doping

ABSTRACT
Herein, we show that incorporation of ions during biomimetic coating deposition may be utilized to tailor the drug loading capacity of hydroxyapatite (HA) coatings. Pure biomimetic HA (HA-B) and Si-doped equivalents (SiHA-B) where deposited by a biomimetic process onto titanium dioxide covered titanium substrates. The antibiotic Cephalothin was incorporated into the coatings by adsorptive loading and the release was studied in-vitro. SiHA-B coatings exhibited superior drug incorporation capacity compared to pure HA-B coatings, resulting in a drug release profile dominated by an initial 10 min burst effect while a more prolonged 10 hour release was observed from HA-B coatings. The results emphasize the possibility to impact the drug release kinetics from implant coatings by selective doping elements and the use of thin, biomimetic HA-coatings as drug delivery vehicles. Functionalizing metal implants with SiHA-B coatings presents an interesting strategy towards creating synergetic effects through ion- and antibiotic release and, hence, contributing both towards preventing post-surgical infections while at the same time enhancing the bone-bonding ability.
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