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Effect of Sintering Processes on Surface Properties and Protein Adsorption of Hydroxyapatite Ceramic Particles

Author(s): ZHANG Hui-Jie, ZHU Xiang-Dong, WANG Xin-Long, FAN Hong-Song, ZHANG Xing-Dong

Journal: Journal of Inorganic Materials
ISSN 1000-324X

Volume: 25;
Issue: 7;
Start page: 770;
Original page

Keywords: hydroxyapatite ceramics; conventional and microwave sintering; surface property; protein adsorption

Two types of hydroxyapatite (HA) ceramic particles were respectively fabricated by conventional and microwave sintering processes. The conventionally sintered HA was abbreviated as HACS, and the microwave sintered one was HAMS. The phase compositions, surface morphologies and zeta potentials of both particles were respectively analyzed with X-ray diffraction (XRD), scanning electron microscope (SEM) and zetasizer. Bovine serum albumin (BSA) and lysozyme (LSZ) were selected as models to study their adsorption behaviors on HACS and HAMS. Results confirm that both HA particles crystallize completely, but HACS has larger crystal grain size than HAMS. Although both HACS and HAMS show negative surface zeta potentials in phosphate buffered saline (PBS, pH 7.4), the former has higher absolute value than the latter. Besides, both HA particles exhibit different adsorption ability for BSA and LSZ, and HACS adsorbs fewer BSA but more LSZ than HAMS. The microwave sintering can be a good method to produce nano-HA ceramics with excellent bioactivity.
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