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Effect of Sodium Valproate on Ouabain-Induced Arrhythmia in Isolated Guinea-Pig Atria

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Author(s): Abbas Pousti | Ali Zare Jahromi | Golrokh Malihi | Hasan Ojaghzadeh | Kaveh Brumand | Tara Deemyad

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 6;
Issue: 1;
Start page: 41;
Date: 2007;
Original page

Keywords: Sodium valproate | Ouabain | Isolated atria

ABSTRACT
Sodium valproate (SV), an antiepileptic drug has several mechanism of action. It inhibits voltage sensitive Na+ channels and reduces intracellular Na accumulation. These actions are similar to that of both phenytoin and carbamazepine. We have investigated the direct cardiac action of SV and its effects on ouabain-induced arrhythmia in isolated guinea-pig atria. The guinea-pig atrium was dissected out and suspended in modified Krebs solution under physiologic conditions. Drug was added into the solution. The changes in rate and contractions were measured using a physiograph. SV (100-300µg/ml) caused a dose-dependent decrease in contractile force of isolated guinea-pig atria (9-120%, P

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