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The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats

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Author(s): Vijay P | Yeshwanth R | Bairy K

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 40;
Issue: 6;
Start page: 248;
Date: 2008;
Original page

Keywords: Lactate dehydrogenase | sodium valproate | testosterone

ABSTRACT
Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2 nd , 4 th , 5 th , 7 th , 10 th and 15 th week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P< 0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P< 0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.
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