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Effect of stress due to food deprivation, social inequality and instability on brain

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Author(s): Shirin Mahdi Dust | Mohammad Reza Vaez Mahdavi | Susan Kabudanian Ardestani | Reza Sedaghat | Foruzandeh Jalilvand | Marjan Aghajani | Mohsen Khalili | Marjan Aghajani | Armin Azimi | Saeid Arbab Soleymani | Tooba Ghazanfari

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 16;
Issue: 4;
Start page: 350;
Date: 2013;
Original page

Keywords: Social justice | Food inequality | Social stress | Lipofuscin | Mice | Health Equity

ABSTRACT
Introduction: Several reports show a relationship between health equity, and health status and longevity of individuals. In this study, effects of food deprivation, inequality and social instability were investigated on the formation of lipofuscin pigment in Balb/C mice by histopathological and biochemical methods. Methods: Thirty-six male mice were divided into 6 groups, then different kinds of stress (food deprivation, inequality and cage-mate change) were implemented on these groups for 2 weeks according to the protocol. Lipofuscin was biochemically measured in the brain homogenate of one hemisphere by Shen’s method. The other brain hemisphere was used to qualitatively investigate the accumulation of lipofuscin by fluorescent microscope and it was also stained with periodic acid Schiff and examined with light microscope. Results: Food deprivation alone did not cause significant differences in the amount of lipofuscin, but in food deprived and inequality experienced animals the amounts of lipofuscin was well above controls (P
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