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Effect of Surgical Flap on IL-1β and TGF-β Concentrations in the Gingival Crevicular Fluid of Patients with Moderate to Severe Chronic Periodontitis

Author(s): Mandana Sattari | Alireza Fathiyeh | Fatemeh Gholami | Hassan Darbandi Tamijani | Mahdi Ghatreh Samani

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 1;
Start page: 20;
Date: 2011;
Original page

Keywords: Periodontitis | Periodontal Surgical Therapy | Cytokine | IL-1β | TGF-β

Background: Growth factors play a major part in wound healing in many tissues in-cluding the periodontium. Transforming growth factor-β1 (TGF-β1) is one of these fac-tors present in the gingival crevicular fluid. In addition, it is considered as one of the most important anti-inflammatory cytokines. Interleukin-1β is a proinflammatory cyto-kine that presents itself in gingival inflammation and the GCF. Such factors might be of value as prognostic markers of wound healing activity and the therapeutic progress fol-lowing flap surgery. Objective: The aim of this study was to evaluate the effect of sur-gical flap on the concentration of IL-1β and TGF-β in the GCF of patients with moder-ate to severe chronic periodontitis. Methods: The GCF samples were collected, using the Perio-Paper strip at phase 1 (pre-surgery), phase 2 (4th week post surgery) and phase 3 (12th week post surgery) from 20 sites of 10 patients undergoing flap surgery. After the elution, IL-1β and TGF-β concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Results: The mean TGF-β and IL-1β concentration de-creased from phase 1 to phase 3 (p

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