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The effect of tocopherol on serum iron content in experimental atherosclerosis

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Author(s): Vučević Danijela | Pešić B. | Đarmati Danica | Đorđević-Denić Gordana | Radosavljević Tatjana | Todorović Vera N. | Mirković S.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 55;
Issue: 2-3;
Start page: 131;
Date: 2005;
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Keywords: epithelial cells | radiation | radioprotection | rats | thymus | WR-638

ABSTRACT
Phenotypic changes of thymic epithelial cells (TEC) were studied in male Wistarrats subjected to radioprotector WR-638 (358 mg/kg b.w. ip) and/or whole body X-ray irradiation (3.5 Gy) 15 days after its application. Phenotypic changes were identified in situ on cryostat thymic sections using immunohistochemical staining by a panel of monoclonal anti-cytokeratin antibodies. It was shown that WR-638 significantly reduced changes in the structure of the thymus caused by X-ray irradiation. In the primary involution phase some phenotypic characteristic changes of TEC can be explained mostly by lymphoid destruction, although factors directly connected to the protector can not be excluded. However, in the primary regenerative phase WR-638 caused prominent changes of antigen expression on subcapsular and medullary TEC in irradiated rats. Therefore, WR-638 not only protects thymocytes, but also causes alterations of phenotypic characteristics of TEC which may contribute to its beneficial radioprotective effect on the irradiated rat thymus.
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