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The effect of treatment with melatonin upon the ultrastructure of the mouse pineal gland: a quantitative study

Author(s): REDINS G. M. | REDINS C. A. | NOVAES J. C.

Journal: Brazilian Journal of Biology
ISSN 1519-6984

Volume: 61;
Issue: 4;
Start page: 679;
Date: 2001;
Original page

Keywords: pineal gland | melatonin | ultrastructure

In order to evaluate melatonin implication in the regulating of its own secretory process by pinealocytes, we used morphometric techniques for transmission electron microscopy. In mice treated with 100 mg of melatonin (N-acetyl-5-methoxy-tryptamine) by daily subcutaneous injection, we observed a decrease in number and volumetric density of lysosomes. Our results showed that melatonin influences the secretory activity of pinealocytes and participates in a complex secretory regulating mechanism.
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