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Effect of Vitamin E and Selenium Supplements on the Antioxidant Markers and Immune Status in Sheep

Author(s): A.M. Hamam | Hala A.A. Abou-Zeina

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 7;
Issue: 6;
Start page: 870;
Date: 2007;
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Keywords: Vit E immunity | selenium | Antioxidant | ewes

Twenty-one Baladi ewes were used to determine the effects of supplemental Vit E and/or Se on natural antioxidants and immunity. The ewes were randomly assigned into three equal groups; group I, was kept as control; group II, was injected I/M with a solution of sodium selenite (1.7 mg/head, once/two weeks for 16 weeks) and group III, treated with 1 mL of Viteselen 15 (contains 1.67 mg sodium selenite plus 150 mg Vit E /mL). The concentrations of Vit E in diet, serum α-tocopherol and β-carotene were determined using HPLC; whole blood- GPX, E-SOD were estimated kinetically and total serum protein and its fractions as well as Se concentration in diet were determined. The results showed that injection of Vit E and Se (group III) significantly increased the serum concentrations of α-tocopherol and βcarotene at all sampling times, while administration of Se alone did not induce significant alterations. Whole blood GPX-activities increased significantly after the administration of Se either alone or in combination with Vit E at week 4 and onwards, while the activity was enhanced by administration of Se alone. No significant changes could be traced concerning E-SOD activity; total serum protein and albumin in both treated groups. It is concluded that administration of Vit E and Se significantly improved the antioxidant status of ewes and the levels of total globulins specifically γ-globulins (Igs).

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