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Effect of in vitro Glycation of Human Placental Collagen (Type IV) on Platelet Aggregation

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Author(s): Goodarzi Mohammad Taghi | Rezaei Mohsen | Piry Hossein | Amiry Saied

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 8;
Issue: 9;
Start page: 1203;
Date: 2005;
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Keywords: Glycation | collagen | platelet aggregation | human placenta

ABSTRACT
The aim of this study was to analyze the in vitro glyation of human placental collagen (type IV) and to test the effect of glycation on its platelet aggregation activity. After isolation of collagen IV from a normal human placenta, it was glycated using different glucose concentration and different time of incubation. Glycation was measured using thiobarbituric acid colorimetric reaction. Using a turbidimetric method effect of glycated collagen on platelet aggregation was studied and compared with those of non-glycated collagen. The data obtained from this study indicated that collagen underwent in vitro glycation reaction and the level of glycation was dependent on glucose concentration and time of treatment with glucose (p
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