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The effect of Zn2+ on prostatic cell cytotoxicity caused by Trichomonas vaginalis

Author(s): Laura Isabel Vazquez-Carrillo | Laura Itzel Quintas-Granados | Rossana Arroyo | Guillermo Mendoza Hernández | Arturo González-Robles | Bertha Isabel Carvajal-Gamez | M. Elizbeth Álvarez-Sánchez

Journal: Journal of Integrated OMICS
ISSN 2182-0287

Volume: 1;
Issue: 2;
Start page: 198;
Date: 2011;
Original page

Keywords: Trichomonas vaginalis | DU-145 prostatic cells | morphology | Zn2+ proteome | cytotoxicity | TvCP65

Our investigation focused on the study of the proteome, morpholo-gy, and cytotoxicity of T. vaginalis during interactions with prostatic DU-145 cells. The results suggest that approximately 37 different proteins are expressed in the presence of Zn2+, which also down-regulates the protein and transcriptional levels of TvCP65. The result is a negative effect on trichomonal cytotoxicity. The differentially expressed proteins were identified by mass spectrometry analysis.
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