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Effectiveness of Danning Tablet in patients with non-alcoholic fatty liver of damp-heat syndrome type: A multicenter randomized controlled trial

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Author(s): Guang JI

Journal: Zhong Xi Yi Jie He Xue Bao
ISSN 1672-1977

Volume: 6;
Issue: 2;
Start page: 128;
Date: 2008;
Original page

Keywords: fatty liver | dampness-heat (traditional Chinese medicine) | treatment effectiveness | randomized controlled trial

ABSTRACT
Objective: To evaluate the efficacy and safety of Danning Tablet (DNT) in patients with non-alcoholic fatty liver disease (NAFLD) of damp-heat syndrome type.Methods: A multicenter, randomized, double-blinded and positive drug parallel controlled trial was performed. One hundred and thirty-five patients were enrolled into the study and divided into two groups: DNT-treated group (n=102) and ursodeoxycholic acid (UDCA)-treated group (n=33). Body mass index (BMI), principal symptoms, liver function, blood lipids, iconographic, and compositional parameters were measured before and after treatment, respectively.Results: In the two groups, BMI, distress in hepatic region, fatigue, anorexia, liver function, blood lipids and iconographic parameters were significantly improved, and the improvements of BMI, distress in hepatic region were better in DNT-treated group than in UDCA-treated group. The histological study also showed that DNT had positive effect in treatment of NAFLD. Conclusion: DNT is an effective drug to treat patients with NAFLD of damp-heat syndrome type and is more effective than UDCA.
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