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The effectiveness of evening primrose oil and alpha lipoic acid in recovery of nerve function in diabetic rats

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Author(s): Alaa Eldeen Ahmed El-kossi | Mostafa Mahmoud Abdellah | Abeer Mohamed Rashad | Sherifa Ahmad Hamed

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 3;
Start page: 245;
Date: 2011;
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Keywords: Diabetic peripheral neuropathy | evening primrose oil | oxidative stress | alpha lipoic acid

ABSTRACT
Objectives: Diabetic polyneuropathy is a serious complication of diabetes mellitus and the most frequent neuropathy worldwide. Evening primrose oil (EPO) is rich in omega-6 essential fatty acid component and gamma-linolenic acid. Alpha lipoic acid (ALPA) has a protective effect against lipid peroxidation and helps in scavenging free radicals. Data regarding the effect of treatment with EPO on diabetic parameters and neuropathic manifestations are conflicting. This study aimed to determine the therapeutic efficacy of EPO and ALPA in correcting diabetic parameters and functional and structural neuropathic manifestations in streptozotocin (STZ) induced diabetic rats.Materials and methods: In this study, the effects of two week oral treatment with EPO (1.25 g/kg) was compared to that of ALPA (100 mg/kg) and insulin (2 IU/day), utilized singly or in combination.Results: Compared with untreated diabetic rats, EPO and ALPA resulted in reduction of serum levels of glucose (p
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