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Effectiveness of programmes as part of primary prevention demonstrated on the example of cardiovascular diseases and the metabolic syndrome

Author(s): Korczak, Dieter | Dietl, Markus | Steinhauser, Gerlinde

Journal: GMS Health Technology Assessment
ISSN 1861-8863

Volume: 7;
Start page: Doc02;
Date: 2011;
Original page

Keywords: accident | adiposity | apoplexia | apoplexy | behavior therapy | biomedical technology assessment | blinded | blinding | blood glucose | blood sugar | cardiovascular diseases | care | cerebrovascular accident | clinical trial | clinical trials as topic | controlled clinical trial | controlled clinical trials as topic | cost analysis | cost control | cost effectiveness | cost reduction | cost-cutting | cost-effectiveness | costs | costs and cost analysis | decision making | diabetes mellitus | EBM | economic aspect | economics | economics | medical | effectiveness | effectiveness | cost | efficacy | efficiency | ethics | evaluation studies as topic | evidence based medicine | evidence-based medicine | health | health campaign | health care action | health care sector | health economic studies | health economics | health education | health policy | health promotion | health technology assessment | heart disease | heart diseases | high blood pressure | HTA | humans | hypertension | insulin resistance | insult | judgment | juridical | life qualities | life style | lipid metabolism | lipometabolism | medical assessment | medical costs | medical evaluation | meta analysis | meta analysis as topic | meta-analysis | metabolic syndrome | metabolic syndrome X | methods | models | economic | movement | multicenter studies as topic | multicenter trial | nutritional physiological phenomena | overweight | peer review | pharmaeconomics | placebo | placebo effect | prevention | prevention program | prevention research | preventive care | preventive medicine | primary prevention | program effectiveness | program evaluation | prophylaxis | prospective studies | quality of life | random | randomisation | randomised clinical trial | randomised controlled trial | randomised trial | randomization | randomized clinical trial | randomized controlled trial | randomized controlled trials as topic | randomized trial | RCT | rehabilitation | relaxation | research article | research-article | review | review literature | review literature as topic | risk assessment | sensitivity | sickness costs | social economic factors | socioeconomic factors | socioeconomics | specifity | stroke | systematic review | technical report | technology | technology assessment | technology assessment | biomedical | technology evaluation | technology | medical | therapy | treatment | validation studies

Background: The HTA-report (HTA = Health Technology Assessment) deals with the primary prevention of cardiovascular diseases and diabetes mellitus type 2. In 2009 approximately 356,000 people died in Germany due to cardiovascular diseases. According to estimations about 6.3 million people are suffering from diabetes mellitus type 2. The interventions that are subsidized by the public health insurance are mainly focused on sufficient physical activities, healthy nutrition, stress management and the reduction of the consumption of addictive drugs and luxury food. Objectives: Which lifestyle-related measures and/or programmes for primary prevention of cardiovascular diseases and of the metabolic syndrome are effective? To what extent will the health status be improved by these offers? To what extent will existing health resources and skills be strengthened by these offers? Are there any differences regarding the effectiveness among the interventions with respect to different settings or subgroups? Which lifestyle-related interventions and/or programmes for primary prevention of cardiovascular diseases and of the metabolic syndrome are sustainable and cost-effective? Which outcome parameters are in the view of the contributors decisive for the evaluation of the effectiveness? In the view of the contributor are there different values between the outcome parameters? In the view of the payers and other actors are there different values between the outcome parameters? Which ethical and juridical factors have to be considered? Which social and/or socio-economic parameters influence the use of the services and effectiveness? Methods: A systematic literature research is done in 35 databases. For the period 2005 to 2010, reviews, epidemiological and clinical studies as well as economical evaluations which deal with primary prevention programmes regarding cardiovascular diseases or the metabolic syndrome are included. Results: 44 publications meet the inclusion criteria. These studies confirm the effectiveness of the primary prevention programmes. Physical activity programs seem to have a stronger effect than nutrition programmes. Psychological programmes prove as well effectiveness, if they include cognitive behaviour therapy. The identified economical studies indicate that programmes for cardiovascular prevention can be conducted cost-effectively. Interventions that focus on the general population turn out to be particularly cost-effective and sustainable. Discussion: There is a wide range of primary preventive effective lifestyle-related interventions with high evidence. The outcomes and results are consistent with the recommendations of the two identified evidence-based guidelines regarding the recommendations on lifestyle and healthy nutrition. Furthermore, the cost-effectiveness of primary prevention services is proven. With regard to the economical studies it is however worth noting that this result is based on very few publications. The transferability has to be critically assessed as the studies mainly originate from the American health system. Conclusion: On the whole a comprehensive setting approach with educative, somatic, psychosocial and activity therapeutic components is recommended. The sustainability of a prevention intervention must be ensured from programme to programme. Long-term studies are necessary to make valid statements regarding the sustainable effectiveness: There is an essential deficit in the current practiced evaluation of the use of primary prevention services provided by the health insurance – mainly regarding the comprehensive setting approach – regarding the evidence-based evaluation of the prescribed preventive interventions. With regard to the ethical, social and economical evaluation the research situation is deficient. The situation has to be particularly analyzed for the socially deprived and one has to respond to their specific needs for prevention.
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