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Effects of 6-OHDA infusion in the paraventricular nucleus of the hypothalamus on the learning and memory processes in rats

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Author(s): Lucian Hritcu | Alin Ciobica | Vlad Artenie | Sorin Stratulat

Journal: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
ISSN 1582-3571

Volume: 9;
Issue: 3;
Date: 2008;
Original page

ABSTRACT
Male Wistar rats were subjected to right-unilateral 6-hydroxydopamine (6-OHDA) lesion (8μg/3μl and 16μg/3μl) of the paraventricular nucleus of the hypothalamus (PVN) or were sham-operated, and their ability to acquire the operant task was studied by means of Y-maze and radial 8 arm-maze tasks. Lesion of the PVN significantly decreased the spontaneous alternation percentage in Y-maze task, in a dose-dependent manner, suggesting effects on spatial memory, especially on short-term memory. 6-OHDA significantly increased the number of working memory errors and the number of reference memory errors in radial 8 arm-maze task, in a dose-dependent manner, suggesting effects on spatial memory formation. In elevated plus maze measuring anxiety, 6-OHDA significantly diminished anxiety state, in a dose-dependent manner. In summary, we provided that the PVN have a facilitatory effect on learning and memory processes.
Affiliate Program     

Tango Jona
Tangokurs Rapperswil-Jona