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Effects of Aqueous Extracts of Hyyptis suaveolens. Poit on Liver Function in an Experimental Rabbit Model

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Author(s): Ijeh I.I | A. Onyinyechi

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 5;
Issue: 1;
Start page: 27;
Date: 2006;
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Keywords: Hyptis suaveolens | aqueous extracts | liver function

ABSTRACT
Oral administration of crude aqueous of Hyptis suaveolens. Piot to male experimental rabbits at doses 100, 500, and 1000 mg kg 1 body weight resulted in a non-dose dependent weight loss relative to control animals receiving distilled water. Serum protein concentration increased from 9.38 ? 0.53 g dL 1 to 17.68 ? 1.85g dL 1 in the highest dose group. Alkaline phosphatase activity increased in all the test groups (control group 29.9 ? 5.20, while groups II, III and IV had 83.38 ? 52.96, 69.23 ? 26.99 and 83.03 ? 4.23 activity U/L respectively). Serum alanine amino transaminotransferase activity (ALT) was found to be 27.75 ? 4.24, 32.67 ? 6.15, 41.13 + 5.48 and 33.50 ? 3.18 for groups I, II, III and IV respectively while serum aspartate amino transferase activity decreased in all the test groups. Our findings suggest that the use of extracts of hyptis suaveolens in high doses in ethnomedicinal preparation may be accompanied by weight loss and toxic effects on the liver.
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