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Effects of Aqueous Extracts (Leaves and Stem) of Vitex doniana on Carbon Tetrachloride Induced Liver Injury in Rats

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Author(s): D.B. James | O.A. Owolabi | M. Bisalla | H. Jassium

Journal: British Journal of Pharmacology and Toxicology
ISSN 2044-2459

Volume: 1;
Issue: 1;
Start page: 1;
Date: 2010;
Original page

Keywords: Carbon tetrachloride | hepatoprotective | histopathology | liver damage | Vitex doniana

ABSTRACT
Effects of aqueous extracts of leaves and stem of Vitex doniana on carbon tetrachloride induced liver injury in rats was assessed. Thirty- six (36) albino rats were divided into six groups of 6 animals each by the randomized random design method, each were allowed food and water ad libidium. Group I (control) was given olive oil, while the rest groups were injected intraperitoneally with a single dose of CCl4 (1 mg/kg) as a 50% (v/v) solution in olive oil and all animals fasted for 36 h, this was repeated every week for a period of four (4) week after 36 h of induction, group III, IV, V and VI were given extracts of Vitex doniana at concentration dose of 100 and 200 mg/kg body weight. At the end of 4 weeks, weight change and histological sections of organs were examined. There was significant (p
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