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Effects of aspirin on the number of peripheral white blood cells and spleen eosinophils in guinea-pigs

Author(s): Turjačanin-Pantelić Drenka | Pantić I. | Pantić Senka | Garalejić Elijana | Jović Dragana | Arsić Biljana

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 60;
Issue: 4;
Start page: 355;
Date: 2010;
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Keywords: aspirin | leukocyte | granulocyte | eosinophil | guinea pig | spleen

Effects of lysine-acetylsalicylate, a soluble form of aspirin, on the number of peripheral white blood cells (PWBC) and on the number of eosinophil granulocytes in spleen imprints were investigated in outbred male guinea-pigs. The absolute number of PWBC and different leukocyte types were determined by standard technique in a haemocytometer. The number of eosinophils in spleen imprints was determined on 2000 nucleated cells. In a dose of 50 mg/kg or 100 mg/kg b.m., i.p., daily for five days lysine-acetylsalicylate did not change the number of PWBC, lymphocytes, neutrophils and monocytes, in comparison with the controls (p>0.05). However, in a dose of 50 mg/kg, b.m., i.p. daily for 5 days, lysine-acetylsalicylate produced a statistically significant increase in the number of blood eosinophils (p
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