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Effects of "Bioactive" amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks

Author(s): Wang Songbo | Khondowe Paul | Chen Shengfeng | Yu Jianjian | Shu Gang | Zhu Xiaotong | Wang Lina | Gao Ping | Xi Qianyun | Zhang Yongliang | Jiang Qingyan

Journal: Journal of Animal Science and Biotechnology
ISSN 1674-9782

Volume: 3;
Issue: 1;
Start page: 27;
Date: 2012;
Original page

Keywords: Broiler chicks | Feed intake | Hypothalamus | Intracerebroventricular (ICV) | L-leucine | L-glutamate

Abstract Feed intake control is vital to ensuring optimal nutrition and achieving full potential for growth and development in poultry. The aim of the present study was to investigate the effects of L-leucine, L-glutamate, L-tryptophan and L-arginine on feed intake and the mRNA expression levels of hypothalamic Neuropeptide involved in feed intake regulation in broiler chicks. Leucine, glutamate, tryptophan or arginine was intra-cerebroventricularly (ICV) administrated to 4d-old broiler chicks respectively and the feed intake were recorded at various time points. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of Neuropeptide Y (NPY), agouti related protein (AgRP), pro-opiomelanocortin (POMC), melanocortin receptor 4 (MC4R) and corticotrophin releasing factor (CRF). Our results showed that ICV administration of L-leucine (0.15 or 1.5  μmol) significantly (P 
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