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Effects of Convolvulus arvensis (Binweed) on the Activity of Drug Metabolizing Enzymes in Liver of Rats

Author(s): M.E. Al-Bowait | S.E.M. Barakat | M.H. Al-Nazawi | M.E. Barri | A.M. Homeida

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 5;
Issue: 9;
Start page: 729;
Date: 2006;
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Keywords: Convulvulus arvensis | liver | drug metabolizing enzymes | rats

The effects of feeding convulvulus arvensis (binweed) at 0.5 and 1g/rat were investigated. Binweed produced no clinical effects or gross lesions in rats. The plant caused decreased concentration of protein in liver homogenate and inhibited the activity of phase-1 but not phase-2 drug metabolizing enzymes. In view of binweed modulating effects on drug metabolizing enzymes, consumption of binweed by human and animal should be prohibited.

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