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The effects of dietary omega-3 fatty acid supplementation on inflammatory biomarkers in type-2 diabetic patients

Author(s): Ali Malekshahi Moghadam | Ahmad Saedisomeolia | Mahmoud Djalali | Fereshteh Sojoudi

Journal: Journal of School of Public Health and Institute of Public Health Research
ISSN 1735-7586

Volume: 9;
Issue: 3;
Start page: 73;
Date: 2012;
Original page

Keywords: Omega-3 fatty acid | Type-2 diabetes | CRP | TNF-α | IL-2

"nBackground and Aim: Omega-3 fatty acids can reduce inflammation in diabetic patients via special mechanisms. The objective the current study was to investigate the effects dietary omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-α) in type 2 diabetes patients. "nMaterials and Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 57 subjects with type-2 diabetes. The participants were randomly assigned to one of 2 groups receiving either an omega-3 fatty acid supplement (containing 1584 mg eicosapentaenoic acid, 828 mg docosahexaenoic acid, and 338 mg other omega-3 fatty acids) or a placebo tablet (containing 2100 mg sunflower oil) for a period of 8 weeks. "nResults: The serum TNF-α  and IL-2 concentrations decreased significantly in the omega-3 fatty acid group in comparison with the placebo group (in both cases, p
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