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Effects of Dietary Zinc Supplement During Lactation on Longitudinal Changes in Plasma and Milk Zinc Concentration

Author(s): Hassan Mozaffari Khosravi | Beman Ali Jalali | Mohamad Hassan Eftekhari

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 10;
Issue: 8;
Start page: 1313;
Date: 2007;
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Keywords: zinc supplementation | milk zinc | plasma zinc | Zinc | marginal zinc deficiency | dietary zinc intake

Effects of dietary zinc supplement during lactation on maternal zinc plasma and milk zinc concentration through 5 months of lactation were examined. One hundred and thirty eight healthy lactating mothers received a weekly 100 mg elemental zinc supplement (ZS, n = 67) or placebo (PG, n = 71) starting one week postpartum in a double blind, randomized design. Milk and plasma zinc concentrations were determined by atomic absorption spectrophotometer. During the course of study, there was not a significantly difference between ZG and PG groups in dietary zinc and energy intake. The mean plasma zinc concentration at 1st week and 5th month were 134±49.1 and 115.6±23 μg dL-1 (PV = 0.005) for PG group, respectively; that of the ZG group these figures were 124.9±52.8 and 121±27.1 μg dL-1 (PV = 0.38), respectively. The mean serum alkaline phosphatase concentration at 1st week and 5th month were 94.8±37 and 92.6±29.9 iu L-1 for PG group, respectively; that of the ZG group these fissures were 90.5±36 and 90±29 iu L-1 (PV = 0.21), respectively. Milk zinc concentration declined significantly over the course of study for two groups, with the sharpest decline occurring during the first 2 months. The mean monthly zinc concentration of ZG group declined from 310±138 at 1st week to 118±64 μg dL-1 at 5th month (declined by 52%). Corresponding means for PG group were 322±161 and 109±70 μg dL-1 (declined by 60%), respectively. Milk zinc concentration significantly different between two groups at 3 and 4 months. A similar study, however, with different zinc dose and administration manner, in zinc marginal deficient lactating mothers is needed to assess the impact of zinc supplementation on milk zinc concentrations.
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