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Effects of different extracts of Rosa damascena on pentylenetetrazol-induced seizures in mice

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Author(s): Mahmoud Hosseini

Journal: Zhong Xi Yi Jie He Xue Bao
ISSN 1672-1977

Volume: 9;
Issue: 10;
Start page: 1118;
Date: 2011;
Original page

Keywords: Rosa damascena | Rosaceae | anticonvulsants | pentylenetetrazol | seizures | mice

ABSTRACT
Objective: In the present study, the effects of aqueous, ethanolic and chloroformic extracts of Rosa damascena on pentylenetetrazol (PTZ)-induced seizures were investigated in mice. Methods: The animals were divided into the following groups: normal saline control group, diazepam group (3 mg/kg), three aqueous extract groups (100, 500 and 1 000 mg/kg), three ethanolic extract groups (100, 500 and 1 000 mg/kg) and three chloroformic extract groups (100, 500 and 1 000 mg/kg). The extracts, normal saline or diazepam were injected intraperitoneally 30 min before PTZ injection. Latency to the first minimal clonic seizure (MCS) and generalized tonic-clonic seizure (GTCS) and the percent of mortality of rats in each group were recorded. Results: Significant increases in both MCS and GTCS latencies were observed in all the three aqueous extract groups in comparison with the normal saline control group (P

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