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Effects of Different Reconstruction Parameters on CT Volumetric Measurement 
of Pulmonary Nodules

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Author(s): Rongrong YANG | Tielian YU | Ying WANG | Qing WANG

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 15;
Issue: 2;
Start page: 72;
Date: 2012;
Original page

Keywords: Computed tomography | Lung nodule | Volumetry | Algorithms | Slice thickness

ABSTRACT
Background and objective It has been proven that volumetric measurements could detect subtle changes in small pulmonary nodules in serial CT scans, and thus may play an important role in the follow-up of indeterminate pulmonary nodules and in differentiating malignant nodules from benign nodules. The current study aims to evaluate the effects of different reconstruction parameters on the volumetric measurements of pulmonary nodules in chest CT scans. Methods Thirty subjects who underwent chest CT scan because of indeterminate pulmonary nodules in General Hospital of Tianjin Medical University from December 2009 to August 2011 were retrospectively analyzed. A total of 52 pulmonary nodules were included, and all CT data were reconstructed using three reconstruction algorithms and three slice thicknesses. The volumetric measurements of the nodules were performed using the advanced lung analysis (ALA) software. The effects of the reconstruction algorithms, slice thicknesses, and nodule diameters on the volumetric measurements were assessed using the multivariate analysis of variance for repeated measures, the correlation analysis, and the Bland-Altman method. Results The reconstruction algorithms (F=13.6, P
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