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The Effects of Eight-Week Treatment with High Dose Vitamin E on Serum Cholesterol and Triglyceride Level of Patients with Schizophrenia on Olanzapine: A Placebo Controlled Study

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Author(s): Maryam Jazayeri | Fiona Baroyant Salmasi | Padideh Ghaeli | Farshad Hashemian | Shahin Akhondzadeh | Alireza Zahiroddin | Firoozeh Raisi | Kazem Golchin | Hafez Bajoghli | Susan Afghah

Journal: Iranian Journal of Psychiatry
ISSN 1735-4587

Volume: 3;
Issue: 1;
Start page: 43;
Date: 2008;
Original page

Keywords: Cholesterol | Olanzapine | Schizophrenia | Triglyceride | Vitamin E

ABSTRACT
"n  "n Objective: To study the effects of a high dose alpha-tocopherol on serum total cholesterol (TC), triglyceride (TG), and the high density lipoprotein (HDL) levels of patients with schizophrenia receiving olanzapine. "nMethod: Thirty six adults diagnosed with schizophrenia based on DSM-IV who were taking olanzapine for a minimum of thirty days entered this eight-week, double blind, placebo-controlled study. Patients were randomized to receive alpha-tocopherol 400IU or placebo capsules twice a day for 2 weeks, then three times a day for 6 more weeks. Fasting total cholesterol (TC), triglyceride(TG),and HDL levels were measured at the baseline and weeks 4 and 8. "nResults: "nTC, TG and HDL levels did not change significantly during this study. There were no significant differences in TC, TG and HDL levels between the two groups at the baseline and weeks 4 and 8. "nConclusion: High-dose vitamin may not improve triglyceride and cholesterol levels in patients who are already on olanzapine. Further studies with greater number of patients and for a longer duration are needed.
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