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Effects of Electrolytic Lesions of the Ventrolateral Periaqueductal Gray and Nucleus Raphe Magnus on Morphine – Induced Antinociception in the Nucleus Cuneiformi

Author(s): Abbas Haghparast | Mehdi Ordikhani-Seyedlar | Maryam Ziaei | Pegah Azizi | Mohammad Ebrahimzadeh-Sarvestani

Journal: Basic and Clinical Neuroscience
ISSN 2008-126X

Volume: 1;
Issue: 4;
Start page: 26;
Date: 2010;
Original page

Keywords: Nucleus Cuneiformis;Ventrolateral Periaqueductal | Nucleus Raphe Magnus;Electrolytic Lesion;Morphine Analgesia

A B S T R A C TIntroduction: The nucleus cuneiformis (NCF) and ventrolateral periaqueductal gray (vlPAG), two adjacent areas, mediate the central pain modulation and project to the nucleus raphe magnus (NRM). Methods: This study examined whether the antinociceptive effect of morphine microinjected into the NCF is influenced by inactivation of vlPAG and NRM in rats. Animals were bilaterally microinjected with morphine (2.5 µg/0.3 µl saline) into the NCF. Electrolytic lesions were made in vlPAG (0.1 mA, 45 sec) and/or NRM (1 mA, 30 sec). Tail-flick latency (TFL) was measured at 30, 60, 90 and 120 min after microinjection. Results: The results showed that TFLs are significantly decreased in vlPAG+NRM lesions group at 30 (P
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