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The effects of ethanol on paracetamol-induced oxidative stress in mice liver

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Author(s): Mladenović Dušan | Ninković Milica | Vučević Danijela | Čolić Miodrag | Micev Marjan | Todorović Vera | Stanković Milena | Radosavljević Tatjana

Journal: Journal of the Serbian Chemical Society
ISSN 0352-5139

Volume: 78;
Issue: 2;
Start page: 179;
Date: 2013;
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Keywords: ethanol | paracetamol | oxidative stress | liver | mice

ABSTRACT
The aim of our study was to investigate the effects of binge drinking on paracetamol induced oxidative stress in mice liver. Male Swiss mice were divided into groups: control; ethanol-treated group (E) in five subsequent doses of 2 g/kg by orogastric tube; paracetamol-treated group (P) in a dose of 300 mg/kg intraperitoneally; group that received paracetamol 12 hrs after the last dose of ethanol (PE). Blood and liver samples were collected for determination of oxidative stress parameters 6, 24 and 48 hrs after treatment. Prior binge drinking potentiated paracetamol-induced rise in liver malondialdehyde level 48 hours after treatment in comparison with P and E groups (17.14 ± 1.98 vs 13.14 ± 0.82 and 12.99 ± 1.18 μmol/L, p
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