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Effects of Garlic (Allium sativum) on Blood Sugar and Nephropathy in Diabetic Rats

Author(s): S.M.A. Shariatzadeh | M. Soleimani Mehranjani | M. Mahmoodi | M.H. Abnosi | H.R. Momeni | A.R. Dezfulian | M. Noori

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 8;
Issue: 8;
Start page: 1316;
Date: 2008;
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Keywords: Kidney structure | stereology | diabetes | nephropathy | garlic

The aim of this study was to investigate the short term effect of aqueous-ethanolic extract of garlic in preventing and curing nephropathy following induced diabetes in rats using streptozotocin (STZ), with the help of stereological methods. Thirty two male wistar rats were randomly divided into control, control+extract, diabetic and diabetic+extract groups (n = 8). Diabetes was induced by intraperitoneal injection of 60 mg kg-1 of streptozotocin (STZ). Treatment with aqueous-ethanolic extract of garlic (50 mg kg-1 day-1) was followed for four weeks, then the left kidneys were excised and stereological studies were carried out. The results revealed that blood sugar of the diabetic rats was reduced significantly following treatment with garlic extract. The final body weight of both diabetic and diabetic+extract groups didn`t increase significantly, but in control and control+extract groups the body weight increased significantly (p
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