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Effects of Ginkgo Biloba Special Extract EGb 761® in Very Mild Cognitive Impairment (vMCI)

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Author(s): Brigitte Grass-Kapanke | Arija Busmane | Andris Lasmanis | Robert Hoerr | Reiner Kaschel

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 02;
Issue: 01;
Start page: 48;
Date: 2011;
Original page

Keywords: Ginkgo Biloba | EGb 761® | Mild Cognitive Impairment | Memory | Concentration | Randomised Controlled Trial

ABSTRACT
Objective: To assess effects of EGb 761® on cognition and quality of life in subjects with very mild cognitive impair-ment. Methods: We randomized 300 subjects aged 45 to 65 with cognitive complaints and low functioning (more than one standard deviation below appropriate norm) in at least one cognitive test to double-blind treatment with once daily 240 mg EGb 761® or placebo for 12 weeks. Results: The exploratory intention-to-treat analysis showed significant im-provement (p < 0.025, one-sided) beyond practice effects for EGb 761® in a measure of attention (Vienna Test System - Work Performance Series) and trends in favour of EGb 761® in measures of memory (Wechsler Memory Scale III - Faces I, Appointments Test – delayed recall), and perceived physical health (SF36 - factor score Physical Health). Cognitive effects were more pronounced and more consistent (p < 0.025 in 4 of 5 tests) in subjects with lower memory function at baseline. Specifically, practice effects in the more demanding tests were attenuated or absent in these sub-jects. Conclusion: Ginkgo biloba extract EGb 761® improved cognitive functioning and aspects of quality of life in sub-jects with very mild cognitive impairment.

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Tangokurs Rapperswil-Jona

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