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The effects of growth hormone administration on bone density in healthy adult rabbits

Author(s): Ahrari Khafi MS | Soroori S | Nakhjavani M | Mortazavi P | Vajhi AR | Bahonar AR

Journal: Tehran University Medical Journal
ISSN 1683-1764

Volume: 69;
Issue: 1;
Start page: 10;
Date: 2011;
Original page

Keywords: bone density | growth hormone | IGF-I | New Zealand white rabbits | Adult

"nBackground: The effects of growth hormone (GH) on bone density in healthy adults is controversial. This study was performed to evaluate the effects of GH administration on bone density under controlled conditions in healthy adult rabbits."n "nMethods: Twenty healthy adult New Zealand white rabbits of both sexes were included in the study. The rabbits were divided into two groups. The experiment group received human GH and the controls placebo for three months. The density of femur and humerus were measured at proximal epiphysis, mid shaft and distal epiphysis by radiography, aluminum step-wedge and appropriate software. Measurements were performed in five stages, once before and four times after the administration of GH or placebo, with 3-week intervals."n "nResults: The mean concentration of serum insulin-like growth factor I (IGF-I) increased significantly after GH administration (P
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