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Effects of High Vegetables Consumption on Inflammatory and Immune Functions in Human Obesity

Author(s): Salwa M. El-Shebini | Salwa T. Tapozada | Laila M. Hanna | Lobna A. Ghattas | Hamed I. Mohamed

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 7;
Issue: 8;
Start page: 1268;
Date: 2007;
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Keywords: Obesity | anthropometric measurements | interleukin-6 | leptin | immunoglobulins

The aim of this study is to demonstrate the effect of consumption of certain vegetables soup as a source of antioxidant with a low caloric balanced regimen to reduce weight, on the defined inflammation and immune biomarkers. Thirty obese Egyptian women shared in this study which lasted for four weeks. They divided in two groups, group 1 had a mean age 40.26±2.01 years and body mass index (BMI) 35.13±1.06, they followed a low caloric balanced regimen (900-1000 kcal) accompanied with the designed vegetables soup. This soup composed of 30 g different dried vegetables chosen and added to each others according to their antioxidant and palatability contents, to be consumed half hour before lunch and dinner after boiling in water. Group 2 (control) had mean age 41.0±3.85 years and BMI 39.22±1.42, they followed the same hypocaloric balanced regimen only. Relevant anthropometric measurements were taken include weight, height and abdominal I circumference (minimal waist), BMI was calculated. Haemoglobin, blood sugar, total cholesterol (TC), triglyceride, serum zinc (Zn), copper (Cu) and magnesium (Mg) were determined. The serum leptin and interleukin-6(IL-6) as proinflammatory and inflammatory biomarkers were estimated beside the immunoglobulins IgA, IgG and IgM to represent a sort of immunity status. All parameters were done before and after 2 and 4 weeks of the intervention. At the end of the study the body weight, BMI and abdominal I circumference significantly decreased, the decrease in the abdominal I circumference was higher among group 1. Slight insignificant variation were observed in the levels of both haemoglobin and blood sugar. Serum TC was decreased significantly in both groups while serum triglyceride decreased only among group 1. The serum mineral Zn, Cu and Mg showed a sort of variation but all the figures were within the normal ranges. Significant decrease was observed in the serum leptin among the two groups, while insignificant decrease in the mean levels of serum IL-6 was detected among group I only. The three immunoglobulins IgA, IgG and IgM were improved significantly, IgA was significantly correlated with both IgG and IgM, these results were quite apparent in group 1. In conclusion obesity corresponds to a subclinical inflammatory condition with increase level of IL-6 and leptin, accompanied by immunity modulation. The uses of vegetables soup rich in the phenolic compounds as supplement, with the low caloric balanced regimen to reduce weight, proved to improve these effects.

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