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Effects of Lactoferrin-containing Formula in the Prevention of Enterovirus and Rotavirus Infection and Impact on Serum Cytokine Levels: A Randomized Trial

Author(s): Meng-Hsiu Yen | Cheng-Hsun Chiu | Yhu-Chering Huang | Tzou-Yien Lin

Journal: Chang Gung Medical Journal
ISSN 2072-0939

Volume: 34;
Issue: 04;
Start page: 395;
Date: 2011;
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Keywords: bovine lactoferrin | kindergarten children | enterovirus 71 | rotavirus | interferon- | interleukin-10

Background: Lactoferrin has been shown to exhibit anti-enterovirus 71 (EV71) and antirotavirus properties. This trial was conducted to determine whether a formulacontaining bovine lactoferrin (bLF) exerts a protective effect against EV71or rotavirus infection among children from 2 to 6 years old.Methods: A prospective, randomized, single blind clinical trial of an oral supplementcontaining bLF (daily dose approximately 70 to 85 mg) was carried out withhealthy children in a day care center from March 2002 to June 2003. Theincidence of enterovirus or rotavirus infection and the serum level of interferon-gamma (IFN-γ) and interleukin-10 (IL-10) were compared betweenchildren receiving and not receiving bLF.Results: A total of 172 children, 96 in group A, which received bLF, and 76 in groupB which did not receive bLF, completed the trial. During the study period, noEV71 was isolated and seroconversion of EV71 antibodies was noted in onlyone child. Fourteen episodes of presumptive enterovirus infection and 12episodes of presumptive viral enteritis were detected. No significant differences were observed between groups in the incidence of presumptiveenterovirus infection or viral enteritis or the number of laboratory confirmedenterovirus or rotavirus infections. No significant differences were observedin the serum levels of IFN-γ and IL-10 between groups either prior to or following the trial. In both groups, IFN-γ levels increased, but IL-10 wasunchanged following the trial.Conclusion: An oral supplement of bLF at a dose of 70 mg/day did not show any benefitsin the prevention of EV71 or rotavirus infection, or any impact on IFN-γ orIL-10 serum levels in healthy children in this trial.

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