Academic Journals Database
Disseminating quality controlled scientific knowledge

The effects of Leptin on gastric ulcer due to physical and psychological stress: Involvement of nitric oxide and prostaglandin E2

ADD TO MY LIST
 
Author(s): Soghra Fallahi | Fatemeh Nabavizadeh | Seyed Shahabadin Sadr | Ali Mohammad Alizadeh | Soheila Adeli | Hossein Nahrevanian | Hamid Reza Sadeghipour | Gholamreza Hasanzadeh

Journal: Journal of Stress Physiology & Biochemistry
ISSN 1997-0838

Volume: 7;
Issue: 4;
Start page: 301;
Date: 2011;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Leptin | gastric ulcer | nitric oxide | PGE2 | physical stress | psychological stress

ABSTRACT
The present study aimed to assess the effects of Leptin on physical and psychological stresses inducing gastric ulcer. The potential role of endogenous nitric oxide (NO) and prostaglandin E2 (PGE2) in the effects of Leptin on the gastric ulcer in rats are also investigated. In this study, fifty-four male Wistar rats were equally divided into 9 groups and Leptin (10 µg/kg, s.c.) was administered twice a day for 14 days in advance of physical and psychological stress. Also, NG- nitro-l-arginine-methyl ester (L-NAME, 10 mg/kg, an inhibitor of NO synthase) and indomethtacin (5 mg/kg, in order to inhibit PG synthesis) were applied before Leptin administration. Ulcer index, gastric acid secretion, NO metabolites and PGE2 of stomach tissue suspension were all measured. Results indicated that ulcer index and gastric acid secretion were significantly decreased (p
Why do you need a reservation system?      Affiliate Program