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The Effects of Liposome Composition and Temperature on the Stability of Liposomes and the Interaction of Liposomes with Human Neutrophils

Author(s): Omar Moh`d Atrouse

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 5;
Issue: 9;
Start page: 948;
Date: 2002;
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Keywords: Liposomes | phospholipids | cholesterol | fusion | neutrophils | radicals

The effects of temperature and lipid composition on the liposome stability (fusion) in vitro were studied. It has been obscure that temperature affects phosphatidylcholine (PC) liposomes stability and the optical densities of these liposomes were increased with time (days), while incorporation of cholesterol 25 mol % to the liposomes (PC: cholesterol) reduce the temperature`s effects and the optical densities show a very slight change with time (days) because cholesterol in high concentrations prevent the phospholipids packing and induce orientation and more rigidity to those phospholipids and therefore prevent liposome aggregation, even if the oxidation of these lipids takes place (diene production and formation of lyso compounds). Interaction of these liposomes with human neutrophils was also studied. The liposomes containing cholesterol is more efficient in enhancing the activity of these cells than PC liposomes.
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