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Effects of Methanolic Extract of Oxystelma esculentum on Diuresis and Urinary Electrolytes Excretion in Rats

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Author(s): Ashokkumar Durairaj | Upal Kanti Mazumder | Malaya Gupta | Subrata Kumar ray

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 6;
Issue: 2;
Start page: 207;
Date: 2007;
Original page

Keywords: Diuretic activity | Methanol extract | Oxystelma esculentum | Urine volume | Electrolytes excretion

ABSTRACT
The diuretic activity of methanol extract of Oxystelma esculentum aerial parts (MEOE) was studied in male Wister albino rats at 5h and 24h interval. The animals were divided into 5 groups: control, urea, furosemide and 200mg/kg and 400mg/kg MEOE. The extract was administered intraperitoneally (i.p) pretreated and all animals were saline MEOE. The urine volume (in mL) and electrolytes excretion (Na+, K+, Ca2+ and Cl-) at 5h and 24h duration were measured. The urine output increased significantly in urea, furosemide and both MEOE groups (p

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