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The effects of nebivolol on P wave duration and dispersion in patients with coronary slow flow

Author(s): Yılmaz Güneş | Mustafa Tuncer | Ünal Güntekin | Yemlihan Ceylan

Journal: Anadolu Kardiyoloji Dergisi
ISSN 1302-8723

Volume: 09;
Issue: 05;
Start page: 290;
Date: 2009;
Original page

Keywords: Coronary slow flow | nebivolol | P wave dispersion

Objective: Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease. P wave duration and dispersion have been reported to be longer in patients with CSF. Nebivolol, besides its selective beta1-blocking activity, causes an endothelium dependent vasodilatation through nitric oxide release. In this study, we searched for the association between left ventricular diastolic functions and atrial conduction dispersion, the effects of nebivolol on P wave duration and dispersion in patients with CSF. Methods: This prospective case-controlled study included 30 patients having CSF and 30 subjects having normal coronary arteries in coronary angiography. The patients were evaluated with 12-leads electrocardiography and echocardiography before and three months after treatment with nebivolol. The difference between maximum and minimum P wave durations was defined as P-wave dispersion (PWD). Early diastolic flow (E), atrial contraction wave (A) and E deceleration time (DT) and isovolumetric relaxation time (IVRT) were measured. Unpaired and paired t-tests, Chi-square test, Mann-Whitney’s U-test and Pearson correlation analysis were used in statistical analysis. Results: Compared to control group maximum P wave duration (Pmax) (104.3±12.2 vs. 93.4±9.8 msec, p
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