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THE EFFECTS OF NICOTINE TREATMENT ON THE ANTIOXIDANT ENZIMES ACTIVITY IN THE RAT BRAIN

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Author(s): Lucian Hritcu | Calin Maniu | Sorin Stratulat

Journal: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
ISSN 1582-3571

Volume: 8;
Issue: 2;
Date: 2007;
Original page

ABSTRACT
Nicotine has been reported to be therapeutic in some patients with certain neurodegenerative diseases and to have neuroprotective effects in the central nervous system. However, nicotine administration may result in oxidative stress by inducing the generation of reactive oxygen species in the periphery and central nervous system. There is also evidence suggesting that nicotine may have antioxidant properties in the central nervous system. The antioxidant properties of nicotine may be intracellular through the activation of the nicotinic receptors or extracellular by acting as a radical scavenger in that it binds to iron. The possibility that nicotine might be used to treat some symptoms of certain neurodegenerative diseases underlies the necessity to determine whether nicotine has pro-oxidant, antioxidant or properties of both. In the present study we evaluated the effects of nicotine treatment (0.3 mg/kg g.c., i.p., SIGMA, 7 continuous days administration), on the antioxidant enzymes activity.
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