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Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection

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Author(s): Tomofumi Hoshino | Keiji Tabuchi | Akira Hara

Journal: Pharmaceuticals
ISSN 1424-8247

Volume: 3;
Issue: 5;
Start page: 1286;
Date: 2010;
Original page

Keywords: NSAIDs | cochlea | cyclooxygenase | lipoxygenase

ABSTRACT
Cyclooxygenase and lipoxygenase, two important enzymes involved in arachidonic acid metabolism, are major targets of non-steroidal anti-inflammatory drugs (NSAIDs). Recent investigations suggest that arachidonic cascades and their metabolites may be involved in maintaining inner ear functions. The excessive use of aspirin may cause tinnitus in humans and impairment of the outer hair cell functions in experimental animals. On the other hand, NSAIDs reportedly exhibit protective effects against various kinds of inner ear disorder. The present review summarizes the effects of NSAIDs on cochlear pathophysiology. NSAIDs are a useful ameliorative adjunct in the management of inner ear disorders.
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