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Effects of Orange Juice and Hesperetin on Serum Paraoxonase Activity and Lipid Profile in Hyperuricemic Rats

Author(s): Fatemeh Haidari | Mohammad-Reza Rashidi | Majid Mohammad-Shahi

Journal: BioImpacts
ISSN 2228-5652

Volume: 2;
Issue: 1;
Start page: 39;
Date: 2012;
Original page

Keywords: Orange Juice | Hesperetin | Hyperuricemia | Paraoxonase Activity | Lipid Profile | Antioxidant

Introduction: Hypouricemic, antioxidant and xanthine oxidase inhibitory effects of orange juice and hesperetin have been already indicated. The objective of this study was to investigate the effects of orange juice and hesperetin on paraoxonase and arylesterase activity and lipid profile of hyperuricemic rats. Methods: Forty eight male Wistar rats were divided into 8 equal groups of healthy control, healthy+orange juice, healthy+hesperetin, healthy+allopurinol, hyperuricemic control, hyperuricemic+orange juice, hyperuricem-ic+hesperetin and hyperuricemic+allopurinol. Hyperuricemia was induced using potassium oxonate (250 mg/kg ip). The treatments were carried out by daily gavage of 5 ml/kg orange juice, 5 mg/kg hesperetin and 5 mg/kg allopurinol for 2 weeks. Paraoxonase activity in serum was measured spectrophotometrically using paraoxon and phenylacetate as substrates. Serum lipids levels were determined using enzymatic colorimetric methods. Results: Hyperuricemia-induced reduction of paraoxonase and arylesterase activity was restored after treatment with orange juice and hesperetin (p
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