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Effects of regular swimming exercise on the pain threshold following withdrawal syndrome in morphine-dependent rats

Author(s): Farzana Yadegari | Ali Heidarianpour | Farzad Nazem |

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 15;
Issue: 2;
Start page: 288;
Date: 2011;
Original page

Keywords: Addiction | morphine sulfate | naloxan hydrochloride | nociceptive threshold | swimming training

Introduction: Nowadays Opioids are gaining acceptance for the management of moderate to severe and chronic pain. In addition, a number of studies have shown that plasma levels of β-endorphin (βEP) in exercise trained are higher than sedentary rats. In our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. Methods: Male Wistar rats (250±20 g, N=24) were addicted by morphine sulfate 0.4mg/ml (for 21 days) and animals were submitted to swimming training, five days a week for 8 weeks, in which First 60 minutes for 3 weeks and then 90 minutes in two weeks and at the end 120 min for 3weeks. At the end of each stage of exercise protocol naloxan hydrochloride (3mg/kg.ip) was injected. Tail-flick was used to assess the effect of training on nociceptive threshold. Results: Data showed that swimming aerobic exercise significantly increased pain threshold in trained control and addicted rats (p
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