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Effects of Sibutramine on the Treatment of Obesity in Patients with Arterial Hypertension

Author(s): Faria Alessandra Nunes | Ribeiro Filho Fernando Flexa | Lerário Daniel Diniz G. | Kohlmann Nárcia | Ferreira Sandra Roberta Gouvea | Zanella Maria Teresa

Journal: Arquivos Brasileiros de Cardiologia
ISSN 0066-782X

Volume: 78;
Issue: 2;
Start page: 176;
Date: 2002;
Original page

Keywords: sibutramine | obesity | arterial hypertension

OBJECTIVE: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months. METHODS: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo. RESULTS: The group using sibutramine had a greater weight loss than that using placebo (6.7% versus 2.5%; p
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