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Effects of Sildenafil on Dental Tissue

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Author(s): Ferhan Yaman | Sevda Soker | Serhat Atilgan | Behcet Erol | Harun Alp | Serkan Kamil Agacayak | Ahmet Gunay | Bayram Ince | Mehmet Dalli

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 10;
Issue: 9;
Start page: 1124;
Date: 2011;
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Keywords: bone | tissue | experimental research | dental tissue | Sildenafil | dental pulp

ABSTRACT
To investigate the effects of Sildenafil on dental tissue. The study was performed with adult female Wistar-Albino rats. Control group (n = 7) were fed on standard laboratory diet until surgery. The study group (n = 7) were administered Sildenafil orally with orogastric tube 10 mg kg-1 once a day for 30 days. Each rat was anesthetized and mandibular bone with incisor teeth and soft tissue were removed. Dental pulp, dentin, periodental ligament, periodental soft tissue and bone were examined histologically. Neovascularization on the dental pulp and gingiva were significantly higher in the study group. Sildenafil can be used as a supporting factor in dental tissue healing.
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