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Effects of a single incremental exhausting exercise on circulting numbers of lymplocyes subsets in male athletes

Author(s): Ahmad Parsaei Far | Massoud Nikbakht | Mehri Ghafourian Boroujerdnia | Mohammad Reza Zadkarami

Journal: Koomesh
ISSN 1608-7046

Volume: 12;
Issue: 02;
Start page: 189;
Date: 2011;
Original page

Keywords: Immune system | NK cells | T cells | Incremental exhausting test | Flow cytometry

Introduction: Intense exercise activity has been known as one of the immune system suppressor. The purpose of the present study was to examine the effect of a single incremental exhausting exercise on circulting numbers of T cell and NK cell subsets in healthy young male athletes. Material and methods: Twenty male subjects with mean age 22/4±1/8 (SD) yr, mean Vo2max 41/7±7/1 (SD) ml/kg/min and mean BMI 23±1/87 (SD) kg/m2 were divided randomly into two control group (n=10) and experimental group (n=10). The experimental subjects performed a standard bicycle ergometer test whereas the control subjects did not participate in any exercise activity. Blood samples were collected pre-, immediately post-, and 2 hours post-exercise. The T and and NK lymphocyte subsets were analyzed with flow cytometry. Results: There was a significant increase in the percentage of T (CD8) and NK (CD16/56) and a significant decrase in the the percentage of T (CD4) and the ratio of CD4/CD8 from pre-, to immediately post-exercise (p < 0.05). Both changes returned to pre-exercise values at 2 hours post-exercise. Addtionally, no significant changes was found in the percentage of CD56 and CD16 (NK) cells following exercise Conclusion: Findings of this study indicate a single intense and short-term training session caused transient and temporary changes in circulating lymphocytes counts. Thus, it is reommonded that the interval between training designed in a way that the immune system reverts back to its original status.
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